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. Author manuscript; available in PMC: 2020 May 14.
Published in final edited form as: Cell Rep. 2019 Apr 2;27(1):187–198.e6. doi: 10.1016/j.celrep.2019.03.018

Figure 7. Apicidin Confers Cytoprotective Effects upon Skin-Infiltrating PMNs after MRSA Skin Challenge.

Figure 7.

(A) Supernatants from skin tissue homogenates were collected 1 day after infection and subjected to cytokine array analysis (n = 6).

(B) Gating strategies (left) and enumeration of (right) CD31+ CD45−endothelial cells recovered from lesional tissue 1 day following MRSA challenge (± apicidin) or its agr null counterpart (n = 6).

(C) Gating strategies (left) and enumeration of PMNs (right) in PB and skin-draining LNs 1 day after MRSA skin challenge (n = 6).

(D) Gating strategies (left) and corresponding frequency values (right) for propidium iodide+ phagocytic (GFP+) and non-phagocytic (GFP) PMNs recovered from skin lesions 1 day after intradermal challenge with 2 × 107 MRSA GFP+ (± apicidin) or its agr null counterpart (n = 5). Error bars represent SEM. Post-test *p < 0.05 and ***p < 0.001.