TABLE 4.

Patients who underwent multiple surgeries grouped by initial MRI findings

	Surgery 1				Surgery 2				Surgery 3				Further surgeries: invasive, pathology, reason for recurrence, resection	Seizure recurrence
ID	Invasive	Pathology	Resection	Initial MRI	Invasive	Pathology	Reason for recurrence	Resection	Invasive	Pathology	Reason for recurrence	Resection
1	No	Unknown	TL	Cystic lesion	No	Gliosis	Unexplainable by prior findings	TL	SDE + depth	Gliosis	EEG finding elsewhere	TL		Seizure-free
2	SDE	MCD	FL	MCD	SDE	Gliosis	Unexplainable by prior findings	FL	SEEG	MCD	EEG finding elsewhere	FL + insula		Seizure-free
3	No	MCD	FL	MCD	No	MCD	MRI residual lesion	FL	No	NA	Unexplainable by prior findings	Callosotomy		Recurred
4	SDE + depth	MCD	FL	MCD	No	MCD	Unexplainable by prior findings	FL	SDE + depth	MCD	Unexplainable by prior findings	FL		Recurred
5	No	NA	TPO	MCD	Unknown	NA	MRI residual lesion	TPO	No	MCD	MRI residual lesion	TPO		Recurred
6	No	Gliosis	TL	MTS	No	NA	MRI residual lesion	TL	SDE + depth	MTS	MRI residual lesion	TL + FL	Last surgery (total 6 surgeries): no invasive, MCD, EEG findings elsewhere, FL + PL	Recurred
7	No	MTS	TL	MTS	No	MTS	MRI residual lesion	TL	SDE	Gliosis	Unexplainable by prior findings	TL		Recurred
8	No	MTS	TL	MTS	SDE	Gliosis	EEG finding elsewhere	FL + TL	SEEG	Gliosis	EEG finding elsewhere	TPO		Recurred
9	No	MTS	TL	MTS	SDE	Gliosis	Unexplainable by prior findings	TL	SEEG	Gliosis	Unexplainable by prior findings	TL	4th surgery: no invasive, pathology NA, EEG finding elsewhere, insula	Seizure-free
10	SEEG	MTS	TL	MTS	No	MTS	MRI residual lesion	TL	SEEG	MCD	Dual pathology	TL		Seizure-free
11	Depth	NA	TL	NA	SDE	NA	unexplainable by prior findings	PL	SDE + depth	NA	EZ close to eloquent areas	PL	4th surgery: SEEG, gliosis, unexplainable by prior findings, PO	Recurred
12	SDE	MCD	FL	Normal	SDE + depth	MCD	Unexplainable by prior findings	FL	SEEG	Gliosis	EEG finding elsewhere	TL + FL	4th surgery: no invasive, nonspecific, unexplainable by prior findings, FL	Seizure-free
13	SDE	Nonspecific	FL + TL	Normal	No	Gliosis	EEG finding elsewhere	FL + TL	SEEG	Gliosis	EEG finding elsewhere	PO		Recurred
14	No	Tumor	TL	Tumor	No	Tumor	MRI residual lesion	TL	No	Tumor	MRI residual lesion	TL	4th surgery: no invasive, tumor, residual lesion, TL	Recurred
15	No	Tumor	TL	Tumor	No	Tumor	MRI residual lesion	TL	SDE	Tumor	MRI residual lesion	TL	4th surgery: no invasive, gliosis, unexplainable by prior findings, TL	Recurred
16	No	Tumor	TL	Tumor	SDE	Gliosis	EEG finding elsewhere	TL + FL	SEEG	None	Unexplainable by prior findings	TL + FL		Recurred
17	No	Tumor	TL	Tumor	SDE	Gliosis	unexplainable by prior findings	TL	SDE + depth	Gliosis	EEG finding elsewhere	TL + insula	4th surgery: SEEG, gliosis, eloquent areas, TL	Recurred
18	No	Tumor	TPO	Tumor	No	Tumor	MRI residual lesion	TPO	No	Gliosis	Unexplainable by prior findings	TPO		Seizure-free

Abbreviations: depth, depth electrodes; EEG, electroencephalographic; EZ, epileptogenic zone; FL, frontal lobe; MCD, malformation of cortical development; MRI, magnetic resonance imaging; MTS, mesiotemporal sclerosis; NA, not available; PL, parietal lobe; PO, parietal-occipital; SDE, subdural grids; SEEG, stereo-EGG; TL, temporal lobe; TPO, temporal-parietal-occipital.