Table 2. In silico identification of the antimicrobial activities of cuminaldehyde and ciprofloxacin.
Cuminaldehyde | Ciprofloxacin | ||||
---|---|---|---|---|---|
Antimicrobial activities | Pa value | Pi value | Antimicrobial activities | Pa value | Pi value |
Inhibitor of Porphyromonas gingivalis Tpr proteinase | 0.605 | 0.012 | Ophthalmic antibacterial | 0.940 | 0.000 |
Membrane permeability enhancer | 0.516 | 0.012 | Anti-infective | 0.823 | 0.005 |
Antimycobacterial | 0.507 | 0.018 | DNA synthesis inhibitor | 0.786 | 0.004 |
Antiparasitic | 0.491 | 0.017 | Topoisomerase II inhibitor | 0.759 | 0.003 |
Anti-helmintic | 0.487 | 0.006 | Antimycobacterial | 0.638 | 0.008 |
Antifungal | 0.470 | 0.036 | Antibacterial | 0.589 | 0.009 |
Anti-nematode | 0.445 | 0.028 | Quinolone-like antibiotic | 0.572 | 0.001 |
Anti-picornavirus | 0.406 | 0.105 | Anti-cytomegalovirus | 0.448 | 0.004 |
DNA ligase (ATP) inhibitor | 0.401 | 0.016 | Anti-tuberculosis | 0.452 | 0.019 |
Anti-Helicobacter pylori | 0.381 | 0.011 | DNA gyrase inhibitor | 0.488 | 0.001 |
Membrane integrity antagonist | 0.380 | 0.077 | Antibiotic | 0.358 | 0.010 |
Anti-infective | 0.372 | 0.058 | Anti-adenovirus | 0.304 | 0.086 |
Anti-protozoal | 0.352 | 0.060 | |||
Anti-rhinovirus | 0.349 | 0.160 | |||
Antibacterial | 0.336 | 0.047 |
Pa: probability of a compound of being active; Pi: probability of a compound of being inactive.