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. 2020 May 14;15(5):e0232987. doi: 10.1371/journal.pone.0232987

Table 2. In silico identification of the antimicrobial activities of cuminaldehyde and ciprofloxacin.

Cuminaldehyde Ciprofloxacin
Antimicrobial activities Pa value Pi value Antimicrobial activities Pa value Pi value
Inhibitor of Porphyromonas gingivalis Tpr proteinase 0.605 0.012 Ophthalmic antibacterial 0.940 0.000
Membrane permeability enhancer 0.516 0.012 Anti-infective 0.823 0.005
Antimycobacterial 0.507 0.018 DNA synthesis inhibitor 0.786 0.004
Antiparasitic 0.491 0.017 Topoisomerase II inhibitor 0.759 0.003
Anti-helmintic 0.487 0.006 Antimycobacterial 0.638 0.008
Antifungal 0.470 0.036 Antibacterial 0.589 0.009
Anti-nematode 0.445 0.028 Quinolone-like antibiotic 0.572 0.001
Anti-picornavirus 0.406 0.105 Anti-cytomegalovirus 0.448 0.004
DNA ligase (ATP) inhibitor 0.401 0.016 Anti-tuberculosis 0.452 0.019
Anti-Helicobacter pylori 0.381 0.011 DNA gyrase inhibitor 0.488 0.001
Membrane integrity antagonist 0.380 0.077 Antibiotic 0.358 0.010
Anti-infective 0.372 0.058 Anti-adenovirus 0.304 0.086
Anti-protozoal 0.352 0.060
Anti-rhinovirus 0.349 0.160
Antibacterial 0.336 0.047

Pa: probability of a compound of being active; Pi: probability of a compound of being inactive.