Table 2. Humane endpoints–instructions to be followed according to scoring in Table 3.

Score	Instructions
A	Occurrence of one of the signs in category A: intensified observation, if necessary separation within the flock. Occurrence of more than one sign in category A: see instructions for category B
B	Occurrence of one of the signs in category B or more than one sign in category B: intensified observation (at least every three hours between 7 a.m. and 9 p.m.), in order to determine any intensification of the signs, if necessary separation within the flock. In case of combination of group B signs with ataxia, pain, paleness or bleeding, the animal is/the animals are to be euthanized humanely immediately (see category C).
C	Single or multiple animals are removed from the experimental setup and are euthanized humanely immediately using an overdose of isoflurane