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. 2020 May 14;15(5):e0227720. doi: 10.1371/journal.pone.0227720

Fig 2. Loss of Nr1d1 expression increases muscle fiber cross sectional area in young mice but reduces it older mice.

Fig 2

(a) Hematoxylin/eosin (H&E) stained tibialis anterior muscle sections from 6 week old Nr1d1+/+, Nr1d1+/- and Nr1d1-/- mice (b) Quantification of myofiber cross-sectional area (CSA) from 6 week-old Nr1d1+/+, Nr1d1+/- and Nr1d1-/- mice (n = 4) (c) H&E stained tibialis anterior muscle sections from 15 week-old Nr1d1+/+, Nr1d1+/- and Nr1d1-/- mice. (d) Quantified CSA from of TA myofibers from 15 week-old Nr1d1+/+, Nr1d1+/- and Nr1d1-/- mice. CSA determined using ImageJ software. Units displayed are arbitrary units (AU) error bars +/- standard deviation **p<0.01 and ****p<0.0001 determined by One-Way ANOVA.