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. 2020 May 14;15(5):e0227720. doi: 10.1371/journal.pone.0227720

Fig 5. Partial loss of the Nr1d1 gene promotes glucose clearance independent of lean mass levels.

Fig 5

(a) Blood glucose levels in fed mice. (b) Blood glucose levels in mice fasted for 4 h. (c) Glucose tolerance and (d) area under the curve analysis (AUC) of Nr1d1+/+, Nr1d1+/- and Nr1d1-/- mice. (e) Insulin and (f) pyruvate tolerance in Nr1d1+/+ and Nr1d1+/- mice. Mice where age matched male littermates 10–12 weeks of age when conducting GTT, 11–13 weeks of age when conducting the ITT, and 12–14 weeks of age when conducting the PTT (n = 6). GTT and ITT were normalized to the lean mass of the animals. *p<0.05 and **p<0.01 were determined by One-Way ANOVA or Two-Way ANOVA where relevant. Data are expressed as mean ± s.e.m.