Skip to main content
. Author manuscript; available in PMC: 2020 May 14.
Published in final edited form as: Acta Physiol (Oxf). 2018 Oct 22;225(3):e13195. doi: 10.1111/apha.13195

FIGURE 10.

FIGURE 10

Sympathetic denervation upregulates muscle Hdac4, myogenin, and β2-AR expression, and downregulates Gαi2, which is prevented by Gαi2(Q205L) expression. Sympathectomy induces significant increases in Hdac4 in the GA muscle (A) and myogenin in both muscles (B), which significantly decreased with Gαi2(Q205L) treatment. β2-AR significantly increases with sympathectomy and decreases with sympathectomy plus Gαi2 overexpression only in the TA muscle (C). Gαi2 decreased in the TA and GA muscles with sympathectomy, which was prevented by AAV-Gαi2(Q205L) treatment in the TA muscle (D), N = 4 GA or TA muscles from four mice per group. *P < 0.05 and †P < 0.01