Table 1.
Clinicopathologic features of the breast adenomyoepitheliomas studied according to RAS Q61R immunoreactivity
| Clinicopathologic feature | RAS Q61R IHC |
P value* | ||
|---|---|---|---|---|
| Positive (n=5) | Negative (n=21) | |||
| ER | Positive | 0.0% (0) | 66.7% (14) | 0.012 |
| Negative | 100.0% (5) | 33.3% (7) | ||
| Growth pattern | Tubular | 60.0% (3) | 76.2% (16) | 0.5875 |
| Papillary | 40.0% (2) | 23.8% (5) | ||
| Tumor border | Encapsulated | 0.0% (0) | 23.8% (5) | 0.0003 |
| Multinodular | 0.0% (0) | 66.7% (14) | ||
| Infiltrative | 100.0% (5) | 9.5% (2) | ||
| Nuclear grade (epithelium) | Low | 0.0% (0) | 23.8% (5) | 0.0816 |
| Intermediate | 0.0% (0) | 38.1% (8) | ||
| High | 100.0% (5) | 38.1% (8) | ||
| Nuclear grade (myoepithelium) | Low | 0.0% (0) | 4.8% (1) | 0.467 |
| Intermediate | 20.0% (1) | 47.6% (10) | ||
| High | 80.0% (4) | 47.6% (10) | ||
| Epithelial mitoses/ mm2 | <=0.8 | 40.0% (2) | 81% (17) | 0.0494 |
| >0.8 but <=2.1 | 40.0% (2) | 19% (4) | ||
| >2.1 | 20.0% (1) | 0% (0) | ||
| Myoepithelial mitoses/ mm2 | <=0.8 | 0.0% (0) | 85.7% (18) | 0.0013 |
| >0.8 but <=2.1 | 60.0% (3) | 4.8% (1) | ||
| >2.1 | 40.0% (2) | 9.5% (2) | ||
| Necrosis | Absent | 0.0% (0) | 76.2% (16) | 0.0038 |
| Present | 100.0% (5) | 23.8% (5) | ||
*
Two-tailed Fisher’s exact test