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. Author manuscript; available in PMC: 2021 Mar 27.
Published in final edited form as: J Mol Biol. 2020 Feb 13;432(7):2030–2041. doi: 10.1016/j.jmb.2020.01.043

Figure 6. HOXD3 balances BMP9-induced Notch signaling.

Figure 6

(a) Expression of Jagged2 and Dll4 in HUVECs after treatment with BMP9, with or without anti-ALK1 neutralizing antibodies.

(b) Expression of Jagged2 and Dll4 in HUVECs treated with BMP9, with or without infection of lentiviral vectors over-expressing HOXD3.

(c) Expression of Jagged2 and Dll4 in HUVECs after treatment with BMP9, with or without anti-ALK5 neutralizing antibodies.

(d) Angiogenesis assay of HUVECs infected with lentiviral vectors over-expressing HOXD3 and treated with anti-Jagged1 neutralizing antibodies or Dll4 ligands. The vascular coverage was measured and compared between different groups.

(e-f) Migration assay of HUVECs infected with lentiviral vectors over-expressing HOXD3 and treated with anti-Jagged1 neutralizing antibodies or Dll4 ligands.

(g) Schematic diagram.

Data were analyzed by Student’s t test. ***, P<0.001. Error bars are standard deviation. ***, P < 0.001. Scale bar, 50 μm.