Table 3.
Odds ratio (OR) [95% confidence interval (CI)] for the association of restless sleep (a single item) using the Center for Epidemiology Study of Depression (CES-D) with knee pain outcomes stratified by baseline widespread pain status in the Multicenter Osteoarthritis Study
| Restless sleep in past week in the CES-D | ||||
|---|---|---|---|---|
| Knee pain outcomes | More than 3-4 days (Referent group) | 1-2 days | < 1 day | p-trend |
| Consistent frequent knee pain | ||||
| Cross-sectional association for prevalent consistent frequent knee pain (N=4640) | ||||
| Knee (n/N) | 475/1050 (29.6%) | 626/1948 (39.0%) | 504/1642 (31.4%) | |
| OR (95% CI) | 1.0 (ref) | 0.73 (0.60, 0.89) | 0.76 (0.61, 0.94) | 0.03 |
| Longitudinal association for incident consistent frequent knee pain (N=2646) | ||||
| Knee (n/N) | 122/497 (24.4%) | 221/1178 (44.1%) | 158/971 (31.5%) | |
| OR (95% CI) | 1.0 (ref) | 0.91 (0.60, 1.37) | 1.14 (0.70, 1.84) | 0.35 |
| Knee pain worsening (N=4658) | ||||
| Widespread pain absence (N=2746) | ||||
| Knee (n/N) | 81/434 (18.7%) | 253/1174 (21.6%) | 216/1138 (19.0%) | |
| OR (95% CI) | 1.0 (ref) | 1.33 (0.93, 1.91) | 1.11 (0.75, 1.63) | 0.85 |
| Widespread pain presence (N=1912) | ||||
| Knee (n/N) | 222/618 (35.9%) | 243/780 (31.1%) | 157/514 (30.5%) | |
| OR (95% CI) | 1.0 (ref) | 0.78 (0.59 1.02) | 0.73 (0.53, 1.00) | 0.05 |
1
Number of knees: n (knees with pain worsening or incident joint pain) / N (total number of knees)
2
Model adjusted for age (years), sex (men vs. women), race (white vs. non-white), study site, BMI (kg/m2), education level (college and above vs. below college), tobacco use (pack-years), Charlson’s comorbidity index (range 0-9), fatigue (10-point scale), CES-D depression indicator (yes, no), and prescription use of NSAIDs (yes, no).