Fig. 1.

Shows a damaged alveolus with enlarged nuclei and cytologic atypia (a) with abundant DNA (red) and RNA (green) within tissue sections and virally infected cells with an abundance of extracellular DNA and RNA in the cytoplasm (b) co-localized with fibrin and extracellular nucleic acids (c). d is a control lung specimen. Panels e and f show focal degeneration of cardiomyocytes. A pathology hallmark of Covid-19 infection is diffuse small vessel (venule, arteriole and capillary) platelet–fibrin thrombosis and intravascular megakaryocytes in all major organs, including the heart, lungs, kidneys, liver and mesenteric fat. From [9] with permission