Table 1.
Distinguishing laboratory features of disseminated intravascular coagulation, thrombotic microangiopathy and Covid-19- associated coagulopathy
| DIC | Microangiopathy | Covid-19 | |
|---|---|---|---|
| PT | ↑ ↑ | ↔ | ↑ ↑ |
| PTT | ↑ ↑ | ↔ | ↑ |
| Fibrinogen | ↓ | ↔ | ↑ ↑ |
| FDPs | ↑ ↑ | ↔ | ↑ ↑ |
| D-dimer | ↑ | ↔ | ↑ ↑ or ↑ + |
| Platelet count | ↓↓ | ↓ | ↑ or ↔ |
| Peripheral blood Smear + + | + | + + | + |
| VWF | ↑ ↑ | ↔ | ↑ ↑ |
| ADAMTS 13 | ↓ | ↔ | |
| AT | ↓ | ↓ | ↑ |
| ACA | ↔ | ↔ | + |
| PC | ↓ | ↔ | + |
+ ≥ 6 times the ULN
++ peripheral blood smear containing fragmented red blood cells
PT prothrombin time, APTT activated partial thromboplastin time, FDPs fibrin(ogen) degradation products, VWF von Willebrand Factor, ADAMTS-13 a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member, AT antithrombin, ACA anticardiolipin antibodies, PC protein C