2.

CKD患者与对照组凝血功能比较

Comparison of coagulation function between CKD subgroups and control group

Parameter	Control	CKD 1-2	CKD 3-4	CKD 5 non-hemodialysis	CKD 5 hemodialysis	P
CKD: Chronic kidney disease; PT: Prothrombin time; INR: International normalized radio; Fib: Plasma fibrinogen; APTT: Plasma activated partial prothrombin time; AT-Ⅲ: Plasma anti-thrombin Ⅲ; R: Reaction time; K: K-time; MA: Maximal amplitude; CI: coagulation index. aP < 0.05 vs control group; bP < 0.05 vs CKD 1-2 group; cP < 0.05 vs CKD3-4 group.
PT (s)	10.30(9.45, 11.20)	10.00(9.60, 10.75)	10.10 (9.40, 10.50)	10.50 (9.70, 11.60)	10.10 (9.50, 12.00)	0.156
INR	0.91(0.84, 0.98)	0.88(0.85, 0.95)	0.89 (0.83, 0.92)	0.93 (0.86, 1.02)	0.89 (0.84, 1.05)	0.131
Fib (g/L)	2.45(2.25, 2.89)	3.16 (2.58, 3.98)a	3.82 (2.95, 4.84)a	4.34 (3.26, 5.19)ab	3.43 (2.83, 4.03)a	< 0.01
APTT (s)	27.30(24.65, 29.60)	27.90(25.90, 32.45)	27.40(25.30, 30.60)	31.40(27.90, 34.80)a	29.20(25.10, 34.60)	< 0.01
D-Dimer (μg/L)	0.16(0.12, 0.24)	0.41 (0.31, 0.56)a	0.50 (0.24, 0.94)a	0.96 (0.56, 2.65)abc	0.96 (0.41, 1.48)a	< 0.01
AT-Ⅲ(%)	100.70(94.55, 107.45)	92.70(84.80, 104.10)	103.50(81.70, 109.40)	95.10(85.30, 106.70)	80.40(74.60, 102.80)a	0.015
R (min)	4.60(3.50, 5.45)	4.40(2.85, 4.80)	2.80(2.15, 3.60)ab	2.80 (2.20, 3.40)ab	2.40(1.80, 3.40)ab	< 0.01
K (min)	1.70(1.30, 2.20)	1.30(0.95, 1.70)	0.90 (0.80, 1.55)a	0.80 (0.80, 1.00)ab	0.80(0.80, 1.00)ab	< 0.01
α-angle (deg)	68.50 (60.95, 70.35)	68.90 (65.05, 76.00)	77.20 (69.95, 79.30)ab	77.30 (75.30, 79.60)ab	78.00 (74.90, 79.70)ab	< 0.01
MA (mm)	55.65±5.32	62.01±7.48a	65.85±7.08a	68.67±5.95 ab	69.72±5.52ab	< 0.01
CI	0.70(-1.05, 1.80)	1.30(0.50, 3.55)	4.10(2.20, 5.00)ab	4.30 (3.40, 5.10)ab	4.60(3.50, 5.50)ab	< 0.01