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. 2020 Apr;9(2):257–268. doi: 10.21037/tlcr.2020.03.04

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2020 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Specimen-evaluation flowchart. (A) All surgically resected specimens were examined initially by IHC and mRNA-ISH. FISH was performed for samples that were ALK-IHC-positive and ALK mRNA-ISH-positive. (B) mRNA-ISH and FISH were carried out with six representative TBB samples, including ALK-IHC-positive samples or samples with an EGFR or KRAS mutation (as confirmed by molecular testing). IHC, immunohistochemistry; ISH, in situ hybridization; FISH, fluorescence in situ hybridization; ADC, adenocarcinoma; EGFR, epidermal growth factor receptor; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.