Table 3. Characteristics of six adenocarcinomas obtained by transbronchial biopsy (TBB).
| No. | Age | Sex | Smoking status | Stage | Histology | EGFR mutation | KRAS mutation | mRNA-ISH [score] | IHC [intensity, proportion] | FISH [%] |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 73 | F | – | IV | ADC lepidic + micropap | – | – | + [3] | + [3, 3] | + [66] |
| 2 | 67 | M | + | IIA | Mixed ADC (solid + acinar + pap) | – | – | + [1] | + [3, 3] | + [28] |
| 3 | 77 | M | + | IB | Mixed ADC (pap wco non-muc MIA + micropap) | – | – | + [2] | + [2, 3] | + [37] |
| 4 | 59 | F | – | IV | ADC | E746–A750 | – | – [0] | + [0, 0] | – [8] |
| 5 | 76 | F | – | IIIB | ADC | L858R | – | – [0] | + [0, 0] | Indeterminant |
| 6 | 54 | F | + | IV | Poorly differentiated ADC | – | G12C | + [1] | + [0, 0] | – [8] |
Two patients (No. 2 and 3) underwent preoperative bronchoscopy and their TBB specimens were examined by ALK-IHC. Advanced-stage patients were treated with tyrosine kinase inhibitors or systemic chemotherapy. ALK, anaplastic lymphoma receptor tyrosine kinase; IHC, immunohistochemistry; ISH, in situ hybridization; FISH, fluorescence in situ hybridization; ADC, adenocarcinoma; MIA, minimally invasive carcinoma; micropap, micropapillary; muc, mucinous; wco, with components of.