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. 2020 Apr;9(2):294–305. doi: 10.21037/tlcr.2020.03.26

Figure 3.

Figure 3

Changes in LATS2-to-LATS1 ratios modulated cisplatin-induced apoptosis in lung AD cell lines. (A) Both control and LATS2-transfected CL1-0 cells were treated with or without 20 μM cisplatin for 72 hours. The levels of cisplatin-induced apoptotic cells were measured by Annexin V assay (n=4); (B) CL83 cells were treated as described in (A); (C) the expression levels of indicated proteins in control and LATS2-transfected CL1-0 and (D) CL83, were analysed by Western blotting (n=4); (E) apoptotic levels were determined in control and LATS2-silenced H2023 cells with 50 μM cisplatin treatment for 72 hours (n=4); (F) the expression levels of indicated proteins in control and LATS2-silenced H2023 were analysed by Western blotting (n=4). *, P<0.05; **, P<0.01; ***, P<0.001. AD, adenocarcinoma.