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. 2020 Apr;9(2):294–305. doi: 10.21037/tlcr.2020.03.26

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2020 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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LATS2 kinase regulated the subcellular localisation of LATS1 kinase, and nuclear translocation of LATS1 in lung AD cell lines. (A,B) Both control and LATS2-transfected CL1-0 and CL83 cells were treated with or without 20 μM cisplatin for 72 hours. After treatment, cells were immunofluorescence stained with LATS1-specific or LATS2-specific antibodies conjugated with distinct fluorescent probes (n=3); (C) the same method with 50 µM cisplatin was used in both control and LATS2-silenced H2023 cells (n=3). (A,B,C) Magnification, 40×. Scale bar 20 µm; (D) quantitative analysis of nuclear and cytoplasmic ratio of LATS1 in three lung AD cell lines. *, P<0.05; **, P<0.01; ***, P<0.001. AD, adenocarcinoma.