Table 1.

Study Design Recommendations for Application of the IDP Model Approach and Contribution of Specimen to Derive Quantitative Information. Hct: Hematocrit

Quantitative information gained from IDP approach	Requirements	Specimen measured
		Pre-filter Plasma	Post-filter Plasma	Effluent	Cumulated effluent	Volume cumulated effluent	Hct pre-filter (once)	Hct postfilter (frequently)
Accurate and precise determination of RRT clearance Quantification of adsorption to the dialysis membrane Quantification of drug degradation in the cumulated effluent Verify and correct for dilution processes occurring in CVVH(D)F Estimation of effluent flow rate		X	X	X	X	X	X	X
No correction for dilution processes possible	No filtration processes (only CVVHD)	X	X	X	X	X	X
No estimation of effluent flow rate possible		X	X	X			X	X
No correction for dilution processes possible No estimation of effluent flow rate possible	No filtration processes (only CVVHD)	X	X	X			X
No quantification or detection of adsorption processes possible	Adsorption excluded	X		X	X	X
No quantification or detection of adsorption processes possible No quantification of degradation in the cumulated effluent possible	Adsorption excluded, Degradation determined	X			X	X