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FVII antigen levels (black triangles, fraction of baseline) and prothrombin times (PT; fold-increase) over time. Each animal received up to 8 doses of FVII–ASO (50 mg/kg/dose) over a 2-week period (as indicated by the grey shaded box). Dosing of FVII–ASO was stopped once PT reached two-fold prolongation compared to baseline.
