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. 2020 May 8;11:579. doi: 10.3389/fphar.2020.00579

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Copyright © 2020 Wang, Xu, Guo, Huang, Ha, Zhang, Bai, Cui, He and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QX1 formula ameliorates cognitive deficits in septic mice. Mice were randomized divided into sham, CLP, CLP treated with QX1 formula, and CLP treated with DEX groups. Mice were treated with QX1 formula (2 g/kg) or DEX (1 mg/kg) beginning at 2 h after CLP surgery. DEX was used as a positive control. In the Morris water maze test, (A) Escape latency, (B) swimming distance, (C) swimming speed, and (D) the percentage of time spent in the target quadrant on the fifth day are presented respectively. (E) Recognition index, and (F) time spend with novel object in the novel object recognition task were presented respectively. Data were shown as mean ± SD (n=8-12 per group). (G) The flow chart of Morris water maze test and novel object recognition task. ^# p < 0.05 vs. sham, *p < 0.05 vs. CLP, For Morris water maze test, two-way ANOVA; for novel object recognition task, one-way ANOVA.