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. 2020 May 8;11:579. doi: 10.3389/fphar.2020.00579

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Copyright © 2020 Wang, Xu, Guo, Huang, Ha, Zhang, Bai, Cui, He and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QX1 formula ameliorates emotional dysfunction in septic mice. Mice were randomized divided into sham, CLP, CLP treated with QX1 formula, and CLP treated with DEX groups. Mice were treated with QX1 formula (2 g/kg) or DEX (1 mg/kg) beginning at 2 h after CLP surgery. DEX was used as a positive control. In the elevated plus maze, (A) open arm entries, (B) closed arm entries, (C) time spent in the open arms, and (D) time spent in the closed arms were evaluated respectively. In the open field task, (E) the number of crossings and (F) rearings, (G) total distance traveled, and (H) percentage of center duration in the 5 min test were presented respectively. (I) the flow chart of open field task and elevated plus maze test. Data were shown as mean ± SD (n=8-12 per group). ^# p < 0.05 vs. sham, *p < 0.05 vs. CLP, ^△ p < 0.05 vs. training, one-way ANOVA. CLP, Cecal Ligation and Puncture; QX1, Qiang Xin 1; DEX, dexamethasone.