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. 2020 May 8;11:579. doi: 10.3389/fphar.2020.00579

Figure 5.

Figure 5

QX1 formula ameliorates peripheral and central inflammatory responses in septic mice. Mice were randomized divided into sham, CLP, CLP treated with QX1 formula, and CLP treated with DEX groups. Mice were treated with QX1 formula (2 g/kg) or DEX (1 mg/kg) beginning at 2 h after CLP surgery. DEX was used as a positive control. Levels of inflammatory factors were determined by ELISA. Levels of TNF-α, IL-1β, and IL-6 at day 1 (A) and day 10 (B) in serum of septic mice. Levels of TNF-α, IL-1β, and IL-6 at day 1 (C) and day 10 (D) in the hippocampus of septic mice. Levels of TNF-α, IL-1β, and IL-6 at day 1 (E) and day 10 (F) in the frontal cortex of septic mice. Data were shown as mean ± SD (on day 1, n=12-15 per group; on day 10, n=15 per group). # p < 0.05 vs. sham, *p < 0.05 vs. CLP, one-way ANOVA. CLP, Cecal Ligation and Puncture; QX1, Qiang Xin 1; DEX, dexamethasone.