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. 2020 May 8;11:579. doi: 10.3389/fphar.2020.00579

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Copyright © 2020 Wang, Xu, Guo, Huang, Ha, Zhang, Bai, Cui, He and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QX1 formula reduces microglia activation in septic mice. Representative Iba-1 and DAPI immunofluorescence staining in (A) the CA1 area of the hippocampus and (B) the frontal cortex in mice treated with QX1 formula or DEX beginning at 2 h after CLP surgery. Scale bar = 100 μm. (C, D) Statistical analysis of Iba-1 positive cell counts in the hippocampus and the frontal cortex. (E) Statistical analysis of Iba-1 positive cell body area in the hippocampus (n=10 per group, three slices per animal). Data were shown as mean ± SD. ^# p < 0.05 vs. sham, *p < 0.05 vs. CLP, one-way ANOVA. QX1, Qiang Xin 1; CLP, Cecal Ligation and Puncture.