Table 3.

Association between genetic polymorphisms and toxicity.

Gene	Polymorphism	Genotype/diplotype	Skin rash (grade)			P	Diarrhea (grade)			P
			0	1	2+		0	1	2+
ABCB1	rs1045642	G/G	7	20	7	0.614	27	6	1	0.005
		G/A	8	21	10	0.280	25	14	0	0.154
		A/A	1	7	6		4	9	1
ABCB1	rs1128503	G/G	2	3	1	0.471	4	2	0	0.007
		G/A	8	23	10	0.747	33	7	1	1.000
		A/A	6	22	12		19	20	1
ABCG2	rs2231142	G/G	9	26	13	1.0	33	14	1	0.554
		G/T	6	18	8	1.0	18	13	1	1.000
		T/T	1	4	2		5	2	0
ABCG2	rs2622604	C/C	10	26	16	1.0	33	18	1	1.000
		C/T	6	20	6	0.434	21	10	1	1.000
		T/T	0	2	1		2	1	0
ABCG2	rs7699188	G/G	15	43	19	0.681	49	26	2	1.0
		G/A	1	5	4	0.445	7	3	0	1.0
CYP1A1	rs1048943	C/C	2	5	4	0.680	7	4	0	0.687
		C/T	6	15	4	0.326	18	6	1	1.000
		T/T	8	28	15		31	19	1
CYP2D6	rs1065852	G/G	2	9	6	0.822	11	5	1	0.958
		G/A	7	16	11	0.200	21	13	0	0.501
		A/A	7	23	6		24	11	1
CYP3A4	rs2242480	C/C	5	27	8	0.277	21	17	2	0.088
		C/T	11	20	13	0.139	32	12	0	0.275
		T/T	0	1	2		3	0	0
CYP3A5	rs776746	C/C	3	19	8	0.337	14	14	2	0.048
		C/T	11	25	10	0.264	34	12	0	0.217
		T/T	2	4	5		8	3	0
CYP1A2	rs762551	C/C	0	7	4	0.300	5	5	1	0.295
		C/A	8	10	20	0.029	24	13	1	0.241
		A/A	8	21	9		27	11	0
CYP1A2	rs2470890	C/C	13	41	20	0.210	45	17	2	0.634
		C/T	2	7	3	1.000	10	2	0	1.000
		T/T	1	0	0		1	0	0

First row, grade 0 versus 1+; second row, grade 0–1 versus 2+; p ≤ 0.05 was considered statistically significant.