Table 1.
Heptapeptide sharing between HCMV and human proteins related to neuronal migration.
| HCMV heptapeptide 1 | Occurrences in the human proteome 2 | Occurrences in the set of proteins related to neuronal migration 3 | Human proteins related to neuronal migration 4 , 5 | ||
|---|---|---|---|---|---|
| UniProt Name | Cellular location 6 | Protein expression in the hippocampus 7 , 8 | |||
| AVENGDS | 0 | 1 | SAV1 | I | l |
| DRGGGGG | 0 | 1 | SHH | I | – |
| KPGASAA | 0 | 1 | MAGI2 | I | M |
| LKPGASA | 0 | 1 | MAGI2 | I | M |
| LLLPPPS | 0 | 1 | ACK1 | I | M |
| QTVTSTP | 0 | 2 | SMAD2 SMAD3 |
I I |
h m |
| STTAAAA | 0 | 1 | BARH2 | I | – |
| YQRFLRE | 0 | 1 | ACK1 | I | M |
| AAGPPEA | 1 | 1 | CAC1B | M | l |
| RRERERR | 1 | 1 | CAC1B | M | l |
| SGLGDLS | 1 | 1 | AP2A | I | l |
| TDSSLEA | 1 | 1 | MK10 | I | M |
| PPAPRGP | 2 | 1 | RTN4 | I | h |
| SGSSASS | 2 | 1 | LMNA | I | h |
| SSGSSAS | 3 | 1 | LMNA | I | h |
| SAVAAAA | 4 | 1 | SOX1 | I | – |
| SEEEDDD | 5 | 1 | TOP2B | I | h |
| SGGAGGG | 5 | 1 | SMAD2 | I | h |
| DNLTLWT | 6 | 1 | 1433E | I | h |
| LAVADLL | 11 | 2 | 5HT2B DRD2 |
M I |
nd m |
| EDDDDDD | 21 | 1 | FGFR1 | I | M |
| AAAAASS | 24 | 1 | SOX1 | I | – |
| SSGGGGG | 26 | 1 | ALK | I | h |
| EEEDDDD | 27 | 1 | APBB1 | I | M |
| AAAAAAP | 30 | 2 | CADM1 VAX1 |
I I |
nd – |
| DDDDDDD | 30 | 1 | FGFR1 | I | M |
| QQPPPPP | 33 | 1 | BARH2 | I | – |
| GAGGGGG | 40 | 1 | SOX1 | I | – |
| AVAAAAA | 43 | 1 | SOX1 | I | – |
| EEEEEDD | 47 | 1 | APBB1 | I | M |
| VAAAAAA | 51 | 1 | SOX1 | I | – |
| AGGGGGG | 56 | 2 | ALK SOX1 |
I I |
h – |
| GGGGGGA | 62 | 2 | ALK SOX1 |
I I |
h – |
| AAAAAAS | 70 | 1 | SOX1 | I | – |
| QPPPPPP | 70 | 1 | BARH2 | I | – |
| SAAAAAA | 72 | 1 | VAX1 | I | nd |
| EEEEEED | 140 | 3 | ndF4 PAK3 RTN4 |
I I I |
nd – h |
| GGGGGGG | 170 | 2 | ALK SOX1 |
I I |
h – |
| SSSSSSS | 173 | 1 | ULK1 | I | – |
| AAAAAAA | 258 | 4 | BARH2 CADM1 SOX1 VAX1 |
I I I I |
– nd – nd |
| EEEEEEE | 301 | 4 | CELR2 NDF4 PAK3 RTN4 |
M I I I |
M nd – h |
1
HCMV heptapeptide sequences in 1-letter aa code.
2
HCMV heptapeptide occurrences in the human proteome, with proteins related to neuronal migration ( Table S1 ) filtered out.
3
HCMV heptapeptide occurrences in human proteins related to neuronal migration.
4
Human proteins related to neuronal migration and sharing HCMV heptapeptide(s). Proteins indicated according to UniProtKB entry name.
5
Data from the Human Protein Atlas (35).
6
I, intracellular; M, membrane.
7
Expression level: nd, not detected; l, low; m, medium; h, high.
8
Data pending.