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. 2020 May 8;11:798. doi: 10.3389/fimmu.2020.00798

FIGURE 5.

FIGURE 5

Phylogenetic clustering of EmACT with TGF-β/activin subfamily members. A non-redundant set of TGF-β superfamily members sequences were aligned and an unrooted neighbor-joining tree was computed by MEGA. EmACT is shown clustering with members of the TGF-β/activin subfamily (pink box), but not with members of the BMP/growth differentiation factor subfamily (blue box). Conserved residues in the C-terminal region of each homolog (final 94–106 amino acids) were used in the analysis. Percentages at branch points are based on 1,000 bootstrap runs.