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Graphical abstract. Behavioral impact of the PI3K/Akt signaling pathway. Experimental design: 3-days battery of four behavioral tests to assess the Research Domain Criteria (RDoC), negative valence system (NV), and cognitive system (CS) in PDK1−/− and PDK1+/+ mice at young age (YA) and mature age (MA) are illustrated. Main findings are also indicated.
