Table 3.

Multivariate analysis on the influence of age and sex on risk of having potential CYP2C9/2D6/2C19 mediated DDIs.

Multivariate analysis					Sub-group analysis
Variables	Crude OR (95% CI)	P-Value	Adjusted OR (95% CI)	P-Value	Variable	OR (95% CI)	P-Value
CYP2D6 (n = 448)
Age					18–59
18–59	Ref.		Ref.		Men	Ref.
>=60	1.148 (0.918–1.436)	0.228	1.119 (0.956–1.503)	0.116	Women	1.119 (0.881–1.422)	0.358
Sex					>=60
Men	Ref.		Ref.		Men	Ref.
Women	1.289 (1.044–1.592)	0.018	1.319 (1.066–1.632)	0.011	Women	2.159 (1.386–3.363)	0.001
CYP2C19 (n = 490)
Age					18–59
18–59	Ref.		Ref.		Men	Ref.
>=60	1.606 (1.319–1.956)	0.000002	1.640 (1.343–2.002)	0.000001	Women	0.949 (0.754–1.195)	0.659
Sex					>=60
Men	Ref.		Ref.		Men	Ref.
Women	1.064 (0.877–1.291)	0.528	1.139 (0.936–1.385)	0.194	Women	1.691 (1.184–2.416)	0.004
CYP2C9 (n = 187)
Age					18–59
18–59	Ref.		Ref.		Men	Ref.
>=60	0.803 (0.546–1.181)	0.265	0.841 (0.570–1.241)	0.383	Women	1.316 (0.906–1.910)	0.149
Sex					>=60
Men	Ref.		Ref.		Men	Ref.
Women	1.372 (0.986–1.910)	0.061	1.345 (0.964–1.878)	0.081	Women	1.466 (0.702–3.063)	0.308

SD, Standard Deviation; DDI, drug-drug interaction; OR, Odds Ratio; CI, Confidence Interval.