Figure 4.

Dynamic Changes of Hemodynamic and Pulmonary Vascular Remodeling during 4 Weeks of Hypoxia Exposure in Rats

(A–E) The dynamic changes of the carotid pressure (A), the right ventricle systolic pressure (RVSP; B), the ratio of right ventricle weight to left ventricle plus septum weight (RV/(LV + S); C), the pulmonary artery percent wall thickness (WT%; D), and percent wall area (WA%; E) during normoxia or hypoxia exposure in rats. (F) Representative hematoxylin and eosin staining of pulmonary vessels. ∗p < 0.05 versus normoxia; n = 6 for RVSP and RV/(LV + S); n = 60 (muscular arteries) for WT% and WA% (for details, see Materials and Methods). Data are expressed as mean ± SD.