Figure 5.

Therapeutic Effects of HTSFcAng(1-7) Administration on Hypobaric Hypoxia-Induced Pulmonary Hypertension in Rats

(A–C) Administration of adeno-associated virus 9 containing HTSFcAng(1-7) had no significant effects on the mean carotid artery pressure (mCAP; A) but significantly reduced the hypoxia-increased right ventricle systolic pressure (RVSP; B) and the ratio of right ventricle weight to left ventricle plus septum weight (RV/(LV + S); C). (D) Representative hematoxylin and eosin staining of pulmonary vessels. (E and F) The summarized data of pulmonary artery percent wall thickness (WT%; E) and percent wall area (WA%; F). ∗p < 0.05. Data are expressed as mean ± SD, n = 6.