Table 8. Spearman correlations among clinical features and cell cycle pathway genes expression of brain tumors^*.

mRNA	Gender	Type	Survival	Family	Grade	I.R	Area	RB1	CCND1	Ki-67
Age	0.039	−0.037	0.074	0.111	0.06	−0.247‡	−0.22	−0.33	0.126	0.124
Gender		0.02	0.416	0.067	−0.04	0.016	0.195†	0.009	0.104	0.33‡
Type			0.056	−0.058	0.146	−0.027	−0.016	−0.067	−0.132	0.07
Survival				−0.057	0.01	0.108	0.049	−0.150	−0.05	0.171
Family					−0.182†	−0.081	0.005	0.137	−0.016	−0.169
Grade						0.045	−0.117	−0.252†	0.222†	0.103
I.R							−0.051	−0.098	0.072	0.091
Area								0.045	0.047	−0.264†
RB1									−0.337‡	−0.291†
CCND1										0.135

Protein level	Gender	Type	Survival	Family	Grade	I.R	Area	RB1	CCND1	Ki-67
Age	0.039	−0.037	0.074	0.111	0.06	−0.247§	−0.22	−0.29	0.12	0.07
Gender		0.02	0.416	0.067	−0.04	0.016	0.195†	0.32	0.09	0.05
Type			0.056	−0.058	0.146	−0.027	−0.016	−0.12	−0.11	0.13
Survival				−0.057	0.01	0.108	0.049	−0.08	−0.07	0.08
Family					−0.182†	−0.081	0.005	0.06	0.02	0.14
Grade						0.045	−0.117	−0.394‡	0.19	0.54§
I.R							−0.051	−0.16	0.06	0.16
Area								0.08	0.12	0.21†
RB1									−0.54§	−0.29†
CCND1										0.43‡

^*Spearman correlation coefficients. The expression levels of RB1, CCND1 and Ki-67 for the patient cohort were based on the relative mRNA level and protein level. The P-values were computed using one-way ANOVA and χ²-test.

^†P<0.05.

^‡P<0.01.

^§P<0.001.