Table 3. Meta-analysis outcomes at 1-year follow-up.
| Outcome | Studies | Event rate | Odds ratio (95% CI) | I2 | Chi2 | Intergroup difference P value | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| TAVR | SAVR | Overall | Low-risk | Intermediate-risk | ||||||
| All-cause mortality | 5 | 210/3,241 (6.5%) | 219/3,084 (7.1%) | 0.93 (0.76–1.13) | 0.65 (0.40–1.06) | 1.00 (0.80–1.24) | 0% | 3.48 | 0.12 | |
| Cardiac mortality | 5 | 133/3,241 (4.1%) | 158/3,084 (5.1%) | 0.81 (0.64–1.02) | 0.55 (0.32–0.93) | 0.89 (0.68–1.16) | 0% | 2.98 | 0.11 | |
| Stroke | 5 | 165/3,241 (5.1%) | 196/3,084 (6.4%) | 0.77 (0.57–1.05) | 0.70 (0.39–1.25) | 0.79 (0.49–1.27) | 38% | 6.41 | 0.74 | |
| Atrial fibrillation | 4 | 230/2,377 (9.7%) | 761/2,288 (33.3%) | 0.19 (0.13–0.29) | 0.16 (0.13–0.20) | 0.30 (0.24–0.39) | 81% | 15.65 | 0.0002 | |
| Permanent pacemaker | 4 | 326/2,377 (13.7%) | 157/2,288 (6.9%) | 2.88 (1.23–6.72) | 4.17 (1.38–12.59) | 1.18 (0.87–1.60) | 92% | 39.27 | 0.03 | |
| All-cause rehospitalization | 4 | 274/3,096 (8.9%) | 288/2,949 (9.8%) | 0.82 (0.56–1.18) | 0.56 (0.40–0.79) | 1.09 (0.89–1.34) | 74% | 11.49 | 0.001 | |
| Aortic reintervention | 4 | 37/3,096 (1.2%) | 14/2,949 (0.5%) | 2.41 (1.28–4.53) | 1.24 (0.43–3.58) | 3.47 (1.58–7.64) | 0% | 2.63 | 0.13 | |
| Mod-severe paravalvular regurgitation | 4 | 74/2,179 (3.4%) | 10/1,807 (0.6%) | 5.69 (2.68–12.10) | 3.00 (0.60–15.01) | 8.12 (3.48–18.93) | 17% | 3.62 | 0.28 | |
CI, confidence interval; SAVR, surgical aortic valve replacement; TAVR, transcatheter aortic valve replacement.