Table 4. Meta-analysis outcomes at 2-year follow-up.
| Outcome | Studies | Event rate | Odds ratio (95% CI) | I2 | Chi2 | Intergroup difference P value | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| TAVR | SAVR | Overall | Low-risk | Intermediate-risk | ||||||
| All-cause mortality | 5 | 367/2,947 (12.5%) | 377/2,811 (13.4%) | 0.91 (0.75–1.10) | 0.97 (0.67–1.39) | 0.86 (0.64–1.16) | 21% | 5.08 | 0.62 | |
| Cardiac mortality | 4 | 218/2,222 (9.8%) | 234/2,133 (11.0%) | 0.88 (0.72–1.07) | 0.88 (0.50–1.54) | 0.86 (0.67–1.12) | 0% | 2.83 | 0.96 | |
| Stroke | 5 | 178/2,947 (6.0%) | 201/2,811 (7.2%) | 0.77 (0.52–1.15) | 0.61 (0.15–2.39) | 0.88 (0.64–1.19) | 61% | 10.36 | 0.61 | |
| Atrial fibrillation | 3 | 191/1,358 (14.1%) | 418/1,337 (31.3%) | 0.34 (0.21–0.55) | 0.20 (0.12–0.33) | 0.42 (0.25–0.70) | 78% | 9.27 | 0.04 | |
| Permanent pacemaker | 3 | 228/1,358 (16.8%) | 124/1,337 (9.3%) | 3.17 (1.02–9.86) | 8.33 (4.04–17.20) | 2.00 (0.72–5.55) | 93% | 29.37 | 0.03 | |
| All-cause rehospitalization | 2 | 297/1,875 (15.9%) | 233/1,817 (12.9%) | 1.29 (1.07–1.56) | N/A | 1.29 (1.07–1.56) | 0% | 0.56 | n/a | |
| Aortic reintervention | 2 | 16/1,156 (1.4%) | 6/1,156 (0.5%) | 2.68 (1.04–6.87) | 2.83 (0.29–27.55) | 2.65 (0.94–7.45) | 0% | 0.00 | 0.96 | |
| Mod-severe paravalvular regurgitation | 4 | 76/1,101 (6.9%) | 3/933 (0.3%) | 15.32 (5.88–39.91) | 13.52 (1.75–104.6) | 15.87 (5.37–46.88) | 0% | 0.30 | 0.86 | |
CI, confidence interval; SAVR, surgical aortic valve replacement; TAVR, transcatheter aortic valve replacement.