Table 2. Uni- and multi-variate regression analysis of factors associated with CLNM.
| Characteristics | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| P | OR | OR (95% CI) | P | OR | OR (95% CI) | ||
| Gender | |||||||
| Male | 0.012 | 1.433 | 1.081, 1.900 | 0.016 | 1.495 | 1.077, 2.076 | |
| Age (years) | 0.000 | 0.964 | 0.953, 0.975 | 0.000 | 0.973 | 0.960, 0.986 | |
| Background | 0.001 | 0.095 | |||||
| GTβ | 0.000 | 0.559 | 0.409, 0.762 | 0.048 | 0.701 | 0.493, 0.996 | |
| HTγ | 0.052 | 0.896 | 0.629, 1.276 | 0.182 | 0.755 | 0.499, 1.414 | |
| Primary tumor | |||||||
| Size (mm) | 0.000 | 0.973 | 0.960, 0.986 | 0.000 | 1.056 | 1.032, 1.081 | |
| Location | |||||||
| Solitary lesion | 0.537 | – | – | – | – | – | |
| Middle third | 0.215 | 0.799 | 0.560, 1.139 | – | – | – | |
| Lower third | 0.205 | 0.772 | 0.517, 1.153 | – | – | – | |
| Isthmus | 0.986 | 0.992 | 0.429, 2.297 | – | – | – | |
| Multifocality | 0.000 | 2.263 | 1.666, 3.073 | 0.096 | 1.353 | 0.948, 1.932 | |
| Composition | |||||||
| Solid | 0.085 | 0.611 | 0.349, 1.071 | – | – | – | |
| Echogenicity | 0.010 | ||||||
| Hypoechoic | 0.637 | 1.195 | 0.570, 2.503 | – | – | – | |
| Very hypoechoic | 0.554 | 0.801 | 0.385, 1.668 | – | – | – | |
| Shape | |||||||
| Taller-than-wide | 0.617 | 0.933 | 0.711, 1.224 | – | – | – | |
| Margin | 0.073 | ||||||
| ETEδ | 0.035 | 1.748 | 1.040, 2.939 | 0.811 | 0.929 | 0.507, 1.701 | |
| Echogenic foci | 0.000 | 0.070 | |||||
| Macrocalcifications | 0.199 | 1.780 | 0.738, 4.293 | 0.672 | 1.241 | 0.456, 3.382 | |
| Peripheral (rim) | 0.891 | 1.113 | 0.243, 5.089 | 0.880 | 0.870 | 0.143, 5.287 | |
| PEFλ | 0.000 | 2.441 | 1.801, 3.309 | 0.010 | 1.576 | 1.116, 2.226 | |
| Distance (mm) | 0.000 | 0.728 | 0.626, 0.846 | 0.920 | 1.009 | 0.841, 1.212 | |
| uCapsule◎ | 0.000 | 2.205 | 1.709, 2.846 | 0.018 | 1.484 | 1.070, 2.057 | |
| TI-RADS$ Categories | 0.141 | 1.044 | 0.986, 1.107 | – | – | – | |
| uCLNM& | 0.000 | 5.033 | 5.033, 3.791 | 0.000 | 3.498 | 2.561, 4.778 | |
| uLLNM& | 0.000 | 3.905 | 3.905, 2.894 | 0.000 | 1.965 | 1.399, 2.761 | |
β, nodular goiter; γ, Hashimoto’s thyroiditis; δ, extrathyroidal extension; λ, punctate echogenic foci; ◎, capsule invasion in ultrasound; $, Thyroid Imaging, Reporting and Data System; &, CLNM/LLNM in ultrasound. CLNM, central lymph node metastasis; LLNM, lateral lymph node metastasis.