TABLE 1.

Summary of gene ontology analysis of dimer-specific target genes^a

TWIST type	Gene ontologiesb
T0	Cardiac atrium development, olfactory lobe development, endocrine pancreas development, pallium development, hippocampus development
TT	Cardiac atrium development, endoderm development, placenta blood vessel development, mesoderm development, embryonic skeletal system development
T3	Artery development, coronary vasculature development, myeloid leukocyte differentiation, cardiac septum development, regulation of skeletal muscle tissue development
T4	Dendrite development, regulation of erythrocyte differentiation, face development, neuron projection development, regulation of epidermal cell differentiation
T12	Cardiac septum development, dendrite development, cerebral cortex development, positive regulation of dendrite development, cardiac chamber development

^aGene ontology enrichment analysis of genes induced by TWIST1 dimers and TWIST1 monomer against the parental A2LoxCre ESCs. Gene sets were filtered by total gene number of >20 and P value of <0.05.

^bThe top five significant gene ontologies are indicated. Bold, upregulated gene sets; italic, downregulated gene sets.