Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A MAML1-p300 fusion protein can rescue expression of HES4 but not DTX1. (A) Scheme of the designed MAML1-HAT fusion protein. (B and C) RT-qPCR of Notch1-responsive genes HES4 (B) and DTX1 (C) in MAML1 KO Jurkat cells expressing FL, MAML1(Δ151–350), MAML1-HAT, or MAML1-HAT in the presence of a gamma secretase inhibitor (GSI). Data points show the average for technical replicates from each biological replicate, with the three biological replicates indicated using a different point shape.
