Table 1.
Characteristics of survivors of childhood cancer overall and by abdominal radiation exposure and siblings*
| Characteristic | Survivors exposed to abdominal RT | Survivors not exposed to abdominal RT | Siblings(n = 4853) | P† | P‡ |
|---|---|---|---|---|---|
| (n = 4568) | (n = 16 194) | ||||
| Age at cancer diagnosis, y | |||||
| Median (range) | 7.4 (0.0–21.0) | 6.6 (0.0–21.0) | N/A | <.001 | N/A |
| Mean (SD) | 8.8 (5.9) | 7.9 (5.7) | N/A | ||
| Attained age, y | <.001 | <.001 | |||
| Median (range) | 31.6 (10.2–58.3) | 28.6 (8.7–57.9) | 32.7 (0.3–60.3) | — | — |
| Mean (SD) | 31.9 (9.3) | 29.2 (8.5) | 33.0 (9.8) | — | — |
| Follow-up time, y§ | |||||
| Median (range) | 17.7 (2.3–33.9) | 16.3 (2.0–34.2) | N/A | — | — |
| Mean (SD) | 18.2 (7.1) | 16.3 (6.4) | N/A | — | — |
| Race/ethnicity | .051 | <.001 | |||
| White, non-Hispanic | 3738 (81.7) | 13 000 (79.5) | 4190 (86.3) | — | — |
| Black, non-Hispanic | 272 (5.9) | 881 (5.7) | 146 (3.0) | — | — |
| Hispanic/Latino | 116 (2.7) | 547 (3.5) | 90 (1.9) | — | — |
| Other | 334 (7.2) | 1220 (7.3) | 228 (4.7) | — | — |
| Missing | 108 (2.5) | 546 (4.1) | 199 (4.1) | — | — |
| Sex | .55 | <.001 | |||
| Female | 2137 (46.4) | 7614 (47.0) | 2529 (52.1) | — | — |
| Male | 2431 (53.6) | 8580 (53.0) | 2318 (47.8) | — | — |
| Missing | 0 (0.0) | 0 (0.0) | 6 (0.1) | — | — |
| Cancer diagnosis | <.001 | N/A | |||
| Central nervous system tumor | 998 (21.3) | 2869 (14.9) | N/A | — | — |
| Hodgkin lymphoma | 1299 (27.7) | 1390 (7.2) | N/A | — | — |
| Non-Hodgkin lymphoma | 197 (4.2) | 1496 (7.8) | N/A | — | — |
| Leukemia | 501 (13.3) | 5693 (45.3) | N/A | — | — |
| Wilms tumor | 1030 (22.0) | 880 (4.6) | N/A | — | — |
| Neuroblastoma | 333 (7.1) | 1253 (6.5) | N/A | — | — |
| Soft tissue sarcoma | 126 (2.7) | 919 (4.8) | N/A | — | — |
| Bone cancer | 84 (1.8) | 1694 (8.8) | N/A | — | — |
| Body mass index, kg/m2 | <.001 | <.001 | |||
| <18.5 | 547 (11.9) | 1393 (7.9) | 331 (6.8) | — | — |
| 18.5–24.9 | 2242 (48.6) | 7735 (47.3) | 2448 (50.4) | — | — |
| 25.0–29.9 | 989 (21.8) | 3744 (23.3) | 1205 (24.8) | — | — |
| ≥30 | 527 (11.7) | 2424 (15.9) | 716 (14.8) | — | — |
| Missing | 263 (6.0) | 898 (5.6) | 153 (3.2) | — | — |
Counts represent the actual observed number of observations present in the data, and the percentages and P values incorporate the individual sampling weights for survivors, with siblings assumed to have sampling weight of 1. N/A = not applicable; RT = radiation therapy; SD = standard deviation.
Comparison of abdominal RT and no abdominal RT was done using the χ2 test for categorical variables or the Wilcoxon rank sum test for continuous variables; all P values were two-sided.
Comparison of abdominal RT and siblings was performed using the χ2 test for categorical variables or the Wilcoxon rank sum test for continuous variables; all P values were two-sided.
Duration of follow-up starts at 5 years after diagnosis.