Strategy characteristics	Considered values
Age to start screening, y	45*, 55
Age to stop screening, y	75, 77, 80
Screening interval	Annual
Risk-based criteria	Considered values
Evaluated risk-prediction models	Bach, PLCOm2012, LCDRAT
Evaluated risk thresholds	0.9%, 1.0%, 1.1%, 1.2%, 1.3%,
	1.4%, 1.5%, 1.6%, 1.7%, 1.8%,
	1.9%, 2.0%, 2.1%, 2.2%, 2.3%,
	2.4%, 2.5%, 2.6%, 2.7%, 2.8%,
	2.9%, 3.0%, 3.1%, 3.2%, 3.3%,
	3.4%, 3.5%, 3.6%,
	†Risk threshold that yielded a similar sensitivity for ever-smokers in the PLCO control arm as the USPSTF criteria (one for each risk-prediction model)
	‡Risk thresholds that selected a similar proportion of ever-smokers for screening in the PLCO control arm as the USPSTF criteria (one for each risk-prediction model)
Non–risk-based strategies	Description
USPSTF–smoking eligibility criteria	Annual screening for individuals who smoked at least 30 pack-years and currently smoke or quit less than 15 y ago
	The USPSTF criteria was evaluated for screening between age ranges 55–75, 55–77, and 55–80 y

^*Considered only for risk-based strategies that stop screening at age 80 y.

^†Corresponding risk thresholds: PLCOm2012 = 1.83%; Bach = 1.91%; LCDRAT = 1.34%.

^‡Corresponding risk thresholds: PLCOm2012 = 1.36%; Bach = 1.59%; LCDRAT = 0.96%.

LCDRAT = Lung Cancer Death Risk Assessment Tool; PLCO = Prostate Lung, Colorectal, and Ovarian Cancer Screening Trial, USPSTF: United States Preventive Services Task Force.