Table 2.

Methylation of DMR in Gene Promoter Regions of cAMP Signaling Pathway (p = 0.001699)

Gene Name	DMR Location in Promoter Region			DMR (Methylation %)
	Chromosome	Start	End	HG	LG	HG-LG
PDE4C	Chr19	18220846	18221310	85.7	24.91	60.79
PPARα	Chr22	46149487	46149878	94.42	59.47	34.95
HCAR2	Chr12	1.23 × 108	1.23 × 108	87.48	45.91	41.57
GNAS	Chr20	58891431	58891578	35.11	5.71	29.4
CACNA1D	Chr3	53493469	53494019	74.84	25.81	49.03
CAMK2B	Chr7	44221409	44221698	86.07	45	41.07
RAC1P2	Chr4	46724260	46724573	73.99	47.16	26.82
PLD2	Chr17	4806842	4806937	18.7	5.64	13.06
MAPK1	Chr22	21867333	21867621	23.71	3.56	20.15
PIK3R5	Chr17	8888466	8888776	89.6	36.73	52.87
GLP1R	Chr6	39048762	39048955	86.25	59.95	26.3
ADCY1	Chr7	45574683	45574877	59.55	33.76	25.79
PDE4B	Chr1	66331798	66332539	86.73	37.91	48.82
NFATC1	Chr18	79399054	79399517	78.35	33.06	45.29
PDE4D	Chr5	59215742	59215941	94.05	54.39	39.66
VAV3	Chr1	1.08 × 108	1.08 × 108	88.49	24.15	64.34
F2R	Chr5	76715992	76716157	27.58	4.89	22.69
ADCY4	Chr14	24334404	24334719	86.49	53.89	32.6
HCN2	Chr19	587907	588099	56.37	20.45	35.92
GIPR	Chr19	45669075	45669744	83.03	39.41	43.62
HTR4	Chr5	1.49 × 108	1.49 × 108	95.66	78.7	16.96
AL590635.1	Chr6	91816380	91819294	93.85	28.92	64.92
GRIN1	Chr9	1.37 × 108	1.37 × 108	37.91	13.55	24.36
PPP1R1B	Chr17	39630003	39630266	65.33	17.07	48.25
NPR1	Chr1	1.54 × 108	1.54 × 108	76.11	53.96	22.15