Figure 1.

Platelets Boost Inflammasome Activation of Innate Immune Cells

(A–D) IL-1β and TNF-α levels released by unstimulated (Unstim), LPS-primed, and Nigericin, or ATP-activated (A) WT BMDMs, (B) human macrophages (hMDMs), (C) neutrophils, or (D) monocytes. Cells were cultivated alone (−) or with platelets (+Plts) in the indicated ratios. Data is presented as floating bars (with mean and minimum to maximum values) and pooled from at least three independent experiments with cells and platelets from different donors. Each symbol represents the average from technical triplicates per blood donor or mouse.

See also STAR Methods and Figure S1.