Table 3.
Distribution of triggers used in our study with positive predictive values (PPVs) of at least 30% indicative of suspected adverse drug reactions in medical records of emergency department, India
| Trigger | No. of times the trigger was detected | No. of times the trigger was associated with an ADR | PPV (%) |
|---|---|---|---|
| Lithium >1.5 mEq/L | 1 | 1 | 100 |
| Oversedation/hypotension | 19 | 11 | 57.89 |
| Transfusion of blood or use of blood products | 18 | 10 | 55.55 |
| Vitamin K administration | 24 | 13 | 54.16 |
| Phenytoin >20 μg/mL | 2 | 1 | 50 |
| INR >4/>6 | 20 | 10 | 50 |
| Rash | 26 | 13 | 50 |
| Steroid use | 47 | 23 | 48.93 |
| Intubation/reintubation | 18 | 7 | 38.88 |
| (PTT) greater than 100 seconds | 8 | 3 | 37.5 |
| Pruritis | 22 | 8 | 36.36 |
| Antihistamine use | 46 | 16 | 34.78 |
| Clostridium difficile-positive stool | 3 | 1 | 33.33 |
| Pressure ulcers | 3 | 1 | 33.33 |
| Pneumonia onset | 3 | 1 | 33.33 |
| Platelet count <50,000 | 3 | 1 | 33.33 |
| Epinephrine use | 3 | 1 | 33.33 |
| X-ray or Doppler studies for emboli or DVT | 3 | 1 | 33.33 |
| Abrupt medication stop/withdrawn | 162 | 50 | 30.86 |
| Healthcare-associated infections | 10 | 3 | 30 |