Table 1.

Case details of studied patients

	Case 1	Case 2	Case 3	Case 4	Case 5
Age	73 years	64 years	50 years	35 years	29 years
Sex	Male	Male	Female	Male	Female
Total hospital days	25 days	18 days	58 days	16 days	11 days
No. of days of ICU stay	17 days	8 days	12 days	8 days	4 days
Diagnosis	Urosepsis	Aspiration pneumonia following cerebrovascular accident	LRTI with acute kidney injury (AKI) and sepsis/ischemic heart disease and systemic hypertension	Escherichia coli sepsis/foot ulcer/hepatitis E	Peripartum urosepsis with pregnancy-induced hypertension
Sepsis causing organism	Enterococcus faecium—urine culture	Pseudomonas, Staphylococcus aureus in endotracheal tube aspirate	None isolatable	Escherichia coli in both blood culture and wound swab culture	None isolatable—history and investigation suggestive of UTI
	Pan-resistant Klebsiella in blood and urine		Chest X-ray—right lower zone opacity
Organs involved	Kidneys	Kidneys, lungs, brain	Kidney	Kidney, encephalopathy, upper gastrointestinal system	Kidney, uterus, lungs
Indirect hyperbilirubinemia	Absent	Present	Not available	Absent	Absent
Fibrin degradation product	Positive	Not done	Not done	Positive	Not done
LDH elevation in units per liter	515	420	715	3,429	4,207
Complications during stay of patient	Hematuria, hyponatremia, left pleural effusion	Multiple acute infarcts in brain, oliguria, secondary UTI	Post resolution of MAHA with thrombocytopenia, she developed UTI with urosepsis and ICU care	Hypoxia with metabolic acidosis. oliguria with nil output on 8th and 9th day of admission. Hyponatremia. Chicken pox in the preceding week	Couvelaire uterus resulting in cesarean section—baby expired on first day of life. Acute kidney injury with oliguria
				Persistent oral bleed, intubated in view of altered sensorium
				Hepatitis E
Catheter site complications	Nil	Hematoma at catheter site	Nil	Nil	Nil
Plasmapheresis-related complications	Nil	Nil	Nil	Nil	Chills—subsided promptly on medication
Number of peripheral smears done with reports	1st smear—negative for schistocytes—neutrophilic leukocytosis with left shift	1st smear—MAHA	1st smear—MAHA	1st smear—negative for schistocytes—79% neutrophils, left shift	1st smear—negative for schistocytes-—shift to left with neutrophilic leukocytosis and toxic granules
	2nd smear—MAHA	Two repeat smears showed persistent schistocytes.		2nd smear—MAHA	2nd smear—MAHA
Days required after onset of sepsis to diagnose MAHA	4 days	2 days	9 days	2 days	3 days
Number of sessions of plasmapheresis	7 sessions	6 sessions	8 sessions	6 Sessions	5 sessions
Overall outcome	Recovered	Recovered	Recovered clinically from initial episode but developed chronic kidney failure as sequelae	Recovered	Recovered