Table 3.
Sensitivity analysis of the main diagnostic outcome (odds ratio for hepatocellular carcinoma occurrence) performed based on: (a) study design (observational versus RCT); (b) study location (Asia versus western); and (c) study quality (high versus low).
| Variable | Subgroup | Studies (n) | Summary Estimate (95% CI) | Within-Group Heterogeneity (I2) |
|---|---|---|---|---|
| Study design | Observational | 16 | 0.52 (0.41–0.73) | 87% |
| RCT | 3 | 0.98 (0.76–1.32) | 45% | |
| Study location | Asia | 8 | 0.51 (0.43–0.65) | 44% |
| Western | 8 | 0.59 (0.45–0.81) | 34% | |
| Study quality | High | 13 | 0.54 (0.44–0.89) | 39.4% |
| Low | 3 | 0.57 (0.41–0.98) | 55% | |
| Abbreviations: CI, Confidence Interval; RCT, Randomized-Controlled Trial | ||||