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. 2020 Apr 2;10(4):536. doi: 10.3390/biom10040536

Table 4.

Comparison of Drug and Novel Compounds.

Drug GPCR lg Ki Ncr Pi Ei Nvio
Alzheimer’s Disease
Tacrine −0.11 −0.37 −0.93 −0.59 0.43 0
Edrophonium −0.64 −1.59 −1.42 −0.87 0.69 0
Neostigmine −0.22 −0.82 −0.35 −0.07 −0.66 0
Donepezil 0.22 −0.16 0.03 0.03 0.25 0
Pyriostigmine −0.19 −0.86 −2.19 −0.46 0.59 0
Compound GPCR lg Ki Ncr Pi Ei nvio
WG −0.14 0.12 0.13 −0.31 0.23 0
ASTA 0.2 −0.46 0.91 0.28 0.66 0
AG −0.07 0.18 0.34 −0.25 0.26 0
QR −0.06 0.28 0.36 −0.25 0.28 0
LLD −0.45 −0.91 -0.04 −0.33 0.56 0
CCB A 0.45 −0.42 0.79 0.1 0.52 1
CCB B 0.52 −0.4 0.88 0.1 0.56 1
CCB C 0.42 −0.36 0.8 0.12 0.61 1
BMA 0.25 −0.45 0.93 0.29 0.75 1
OX 0.02 −0.06 0.24 −0.06 0.39 1
USA 0.28 −0.5 0.89 0.23 0.69 1
BCSn 0.29 −0.49 0.91 0.19 0.56 1
BTA 0.31 −0.5 0.93 0.14 0.55 1
Spinocerebellar Ataxia
Drug GPCR lg Ki Ncr Pi Ei nvio
Phenytoin 0.07 −0.47 −0.32 0.01 −0.02 0
Primidone −0.06 −0.58 −0.64 −0.38 −0.06 0
Valporic Acid −0.83 −1.55 −0.78 −0.74 −0.39 0
Trimethadione −0.59 −1.44 −1.53 −0.54 −0.6 0
Mephenytoin −0.65 −1.25 −1.68 −0.76 −0.51 0
Lamotrigine −0.16 0.36 −1.12 −0.84 0.08 0
Ethosuximide −0.76 −2.1 −1.7 −1.1 −0.38 0
Ethotoin −0.22 −0.98 −1.32 −0.43 −0.16 0
Oxcarbazepine −0.02 0.1 −0.35 −0.26 −0.2 0
Compound GPCR lg Ki Ncr Pi Ei nvio
ASTA 0.2 −0.46 0.91 0.28 0.66 0
WG −0.14 0.12 0.13 −0.31 0.23 0
LLD −0.45 −0.91 −0.04 −0.33 0.56 0
OX 0.02 −0.06 0.24 −0.06 0.39 1
BCSn 0.29 −0.49 0.91 0.19 0.56 1
BTA 0.31 −0.5 0.93 0.14 0.55 1
D-Mn −0.64 −0.88 −0.88 −0.72 −0.01 1
SGMS 0.12 −0.48 0.74 −0.02 0.53 1
β-SS 0.14 −0.51 0.73 0.07 0.51 1
BCSt 0.21 −0.37 0.56 0.15 0.47 1
HCS 0.04 −0.04 0.04 0.04 0.03 1
OCS 0.04 −0.04 0.04 0.04 0.03 1
NCS 0.04 −0.04 0.04 0.03 0.02 1
TC 0.04 −0.04 0.04 0.03 0.02 1
HTA 0.03 −0.03 0.04 0.03 0.02 1
DOT 0.03 −0.03 0.03 0.03 0.02 1