Table 4.

Comparison of Drug and Novel Compounds.

Drug	GPCR lg	Ki	Ncr	Pi	Ei	Nvio
Alzheimer’s Disease
Tacrine	−0.11	−0.37	−0.93	−0.59	0.43	0
Edrophonium	−0.64	−1.59	−1.42	−0.87	0.69	0
Neostigmine	−0.22	−0.82	−0.35	−0.07	−0.66	0
Donepezil	0.22	−0.16	0.03	0.03	0.25	0
Pyriostigmine	−0.19	−0.86	−2.19	−0.46	0.59	0
Compound	GPCR lg	Ki	Ncr	Pi	Ei	nvio
WG	−0.14	0.12	0.13	−0.31	0.23	0
ASTA	0.2	−0.46	0.91	0.28	0.66	0
AG	−0.07	0.18	0.34	−0.25	0.26	0
QR	−0.06	0.28	0.36	−0.25	0.28	0
LLD	−0.45	−0.91	-0.04	−0.33	0.56	0
CCB A	0.45	−0.42	0.79	0.1	0.52	1
CCB B	0.52	−0.4	0.88	0.1	0.56	1
CCB C	0.42	−0.36	0.8	0.12	0.61	1
BMA	0.25	−0.45	0.93	0.29	0.75	1
OX	0.02	−0.06	0.24	−0.06	0.39	1
USA	0.28	−0.5	0.89	0.23	0.69	1
BCSn	0.29	−0.49	0.91	0.19	0.56	1
BTA	0.31	−0.5	0.93	0.14	0.55	1
Spinocerebellar Ataxia
Drug	GPCR lg	Ki	Ncr	Pi	Ei	nvio
Phenytoin	0.07	−0.47	−0.32	0.01	−0.02	0
Primidone	−0.06	−0.58	−0.64	−0.38	−0.06	0
Valporic Acid	−0.83	−1.55	−0.78	−0.74	−0.39	0
Trimethadione	−0.59	−1.44	−1.53	−0.54	−0.6	0
Mephenytoin	−0.65	−1.25	−1.68	−0.76	−0.51	0
Lamotrigine	−0.16	0.36	−1.12	−0.84	0.08	0
Ethosuximide	−0.76	−2.1	−1.7	−1.1	−0.38	0
Ethotoin	−0.22	−0.98	−1.32	−0.43	−0.16	0
Oxcarbazepine	−0.02	0.1	−0.35	−0.26	−0.2	0
Compound	GPCR lg	Ki	Ncr	Pi	Ei	nvio
ASTA	0.2	−0.46	0.91	0.28	0.66	0
WG	−0.14	0.12	0.13	−0.31	0.23	0
LLD	−0.45	−0.91	−0.04	−0.33	0.56	0
OX	0.02	−0.06	0.24	−0.06	0.39	1
BCSn	0.29	−0.49	0.91	0.19	0.56	1
BTA	0.31	−0.5	0.93	0.14	0.55	1
D-Mn	−0.64	−0.88	−0.88	−0.72	−0.01	1
SGMS	0.12	−0.48	0.74	−0.02	0.53	1
β-SS	0.14	−0.51	0.73	0.07	0.51	1
BCSt	0.21	−0.37	0.56	0.15	0.47	1
HCS	0.04	−0.04	0.04	0.04	0.03	1
OCS	0.04	−0.04	0.04	0.04	0.03	1
NCS	0.04	−0.04	0.04	0.03	0.02	1
TC	0.04	−0.04	0.04	0.03	0.02	1
HTA	0.03	−0.03	0.04	0.03	0.02	1
DOT	0.03	−0.03	0.03	0.03	0.02	1