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Assessment of virotherapy-induced TLR9 activation in HEK-blue TLR9 cells: HEK-blue hTLR9 cells were treated with either viruses or supernatants collected from infected cell cultures for 8 h and analyzed spectrophotometrically. Agonist = ODN2006 (synthetic, unmethylated CpG dinucleotides). The data are shown as means + SEM, n ≥ 4. Statistical significance is determined by Kruskal–Wallis test, treatment compared with mock * p < 0.05; *** p < 0.001.
