Figure 9.

Photomicrographs of H&E-stained sections of the mouse cerebellar cortex of the different study groups: (A) Control group and ceftriaxone group display the molecular cell layer (M) containing small scattered basket cells and stellate cells. Purkinje cell layer (P) contains large pyriform-shaped cells having vesicular open-face nuclei and eosinophilic cytoplasm with prominent Nissl’s granules. The granular cell layer (G) contains crowded small deeply stained cells. (B) ARS group displays few Purkinje cells (P) with deeply stained nuclei, eosinophilic cytoplasm, and is surrounded by vacuolated neuropil. Other Purkinje cells are shrunken with pyknotic nuclei and vacuolated cytoplasm (arrows). (C) ARS group shows Purkinje cells having vacuolated cytoplasm (V) and pyknotic nuclei (black arrows). Basket cells and stellate cells are surrounded with perineuronal spaces (white arrows). (D) ARS + ceftriaxone group. Purkinje cells are increased in number; most of them display open-face nuclei (P) while few of them have darkly stained nuclei and eosinophilic cytoplasm (arrow). (Hx. &E. × 400).