Table 1.
Immunohistochemical detection of pSTAT5 in bone marrow cells of MPN patients and controls.
| Diagnosis | PV | PV | PV | PMF | PMF | PMF | ET | ET | ET | nBM | nBM | nBM | nBM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient # | 18 | 06 | 30 | 20 | 29 | 16 | 34 | 02 | 23 | 46 | 48 | 50 | 51 |
| Megakaryocytes | ++ | ++ | ++ | + | ++ | ++ | ++ | ++ | + | ++ | ++ | ++ | ++ |
| Myeloid prog. | + | + | + | + | + | + | + | +/− | +/− | + | +(+) | + | + |
| Neutrophil gran. | + | + | +/− | + | + | + | + | − | +/− | +/− | + | − | +/− |
| Eosinophil gran. | − | − | − | − | − | − | − | − | n.a. | − | − | n.a. | n.a. |
| Erythroid prog. | − | − | − | − | − | − | − | − | − | − | − | − | − |
Score: ++, strong expression in most cells; +, clear expression in the majority of cases; +/-, expressed in subsets of cells or only weakly expressed; −, no expression (below detection limit). Abbreviations: CM, cutaneous mastocytosis; ET, essential thrombocythemia; gran., granulocytes; MPN, myeloproliferative neoplasm; n.a., not analyzed (no cells found by microscopy); nBM, normal bone marrow; NHL, Non-Hodgkin lymphoma; PMF, primary myelofibrosis; prog., progenitors; PV, polycythemia vera.