Table A3.
IC50 concentrations of JAK2- and STAT5 targeting drugs in pSTAT5 high and low cell lines.
| IC50 Obtained with Drugs in Various Cell Lines (SI pSTAT5) | ||||
|---|---|---|---|---|
| Inhibitor | HEL (13.4) | SET-2 (8.6) | A375 (1.93) | A2780 (1.97) |
| Piceatannol | 10–17.5 | 10–17.5 | >75 | 17.5–25 |
| Pimozide | 5–7.5 | 5–7.5 | 12.5–15 | 12.5–15 |
| AC-3-019 | 3.5–4 | 9–10 | 10–12.5 | 12.5–15 |
| AC-4-130 | 3.5–4 | 7–8 | >15 | >15 |
| AZD1480 | 0.5–1 | 0.05–0.1 | >2 | 0.5–1 |
| TG1010348 | 1–2 | 0.1–0.25 | >2 | 1–2 |
| Ruxolitinib | 1–2 | 0.0025–0.05 | >2 | >2 |
IC50 concentration: half maximal inhibitory concentration; SI: Staining Index (MFI produced by the anti-pSTAT5 antibody:MFI of the isotype-matched control antibody).