Table 1.
Virulence factors and cellular components associated with EMT and H. pylori infection.
| Factors | Increase | Decrease |
|---|---|---|
| Afadin | actin stress fibers; Snail | ND |
| CAFs | α-SMA; Collagen I; Collagen III; COX-2; FAP; FGF-2; FSP1; HGF; HIF-1α; IL-6; IL-8; Integrin β-1; N-cadherin; SDF-1; Snail; TGF-β; TNC; TWIST; VEGF; vimentin | Bcl-2; Ki67 |
| CagA | CD44; Snail 1; vimentin; ZEB1 | CK7; SSP-1 |
| CagA & YAP pathway | CTGF; CYR61; MYC; N-cadherin; Slug; | E-cadherin |
| HB-EGF & MMP-7 | AP-1; NF-κB; Slug; Snail; vimentin | ND |
| LAPTM4B | β-catenin; N-cadherin; Slug; Snail; vimentin; ZEB1 | E-cadherin; ZO-1 |
| Lpp20 | ND | E-cadherin |
| miR-29a-3p | N-cadherin; Snail; vimentin | A20 gene; E-cadherin |
| MSCs | EGF; GM-CSF; IL-1β; IL-6; IL-8; MCP-1; N-cadherin; PDGF-B; TNF-α; VEGF; vimentin | E-cadherin |
| PBP1A mutation | α-SMA; FoxM1 | E-cadherin; miR-134 |
| PDCD4 | Twist1; vimentin | E-cadherin |
| Tipα | Ccl2; Ccl7; Ccl20; Cxcl1; Cxcl2; Cxcl5; Cxcl10; IL-1β; IL-6/STAT3 pathway; IL-8; N-cadherin; NF-κB; TNF-α; vimentin | E-cadherin |
ND—no data.