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. 2020 Apr 17;9(4):1003. doi: 10.3390/cells9041003

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Kinases activation profiling after SOF treatment. (a) Representation of STK kinase activation profiling. (b) Heatmap of kinases with the highest probability of activation in HepG2, HuH-6, and HEK293 cells after SOF treatment sorted from high (red) to low (blue) kinase Z score. (c,d) Pathway analysis of top activated kinases in HepG2 cells (final score >2) based on their enrichment in specific biological processes (GeneGo, corrected p value < 10⁻⁴) (c) or reactome pathways (STRING, false discovery rate < 10⁻⁴) (d). Displayed data represent three independent experiments.